Reactome | AFG3L2:SPG7 degrades SMDT1 (EMRE)

Schema > BlackBoxEvent > Entries

AFG3L2:SPG7 degrades SMDT1 (EMRE) Show undefined attributes

catalystActivity	[CatalystActivity:10907163] ATP-dependent peptidase activity of AFG3L2:SPG7:SMDT1 [mitochondrial inner membrane]
category	omitted
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10907165
displayName	AFG3L2:SPG7 degrades SMDT1 (EMRE)
eventOf	[Pathway:R-DME-9837999] Mitochondrial protein degradation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-9839059] AFG3L2:SPG7 degrades SMDT1 (EMRE) - Homo sapiens
input	[Complex:R-DME-9839141] AFG3L2:SPG7:SMDT1 [mitochondrial inner membrane] [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	AFG3L2:SPG7 degrades SMDT1 (EMRE)
output	[SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix] [Complex:R-DME-9838612] AFG3L2:Zn2+:SPG7:Zn2+ heterohexamer [mitochondrial inner membrane] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-DME-9839053] AFG3L2:SPG7 binds SMDT1 (EMRE) - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-9839059
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-9837999] Mitochondrial protein degradation
(inferredTo)	[BlackBoxEvent:R-HSA-9839059] AFG3L2:SPG7 degrades SMDT1 (EMRE)