Reactome | p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10858705] ubiquitin-ubiquitin ligase activity of p-Pellino:hp-IRAK1:TRAF6 [endosome membrane] [CatalystActivity:10858708] protein kinase activity of TRAF6:hp-IRAK1:Pellino [endosome membrane]
compartment	[Compartment:74700] endosome membrane
consumedByEvent	[Reaction:R-DME-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Drosophila melanogaster [Reaction:R-DME-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10858704
displayName	p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]
hasComponent	[EntityWithAccessionedSequence:R-DME-450815] phospho-Pli [cytosol] [Complex:R-DME-975150] TRAF6:hp-IRAK1 [endosome membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-975143] TRAF6:hp-IRAK1:Pellino [endosome membrane] - Homo sapiens [Complex:R-HSA-975166] p-Pellino:hp-IRAK1:TRAF6 [endosome membrane] - Homo sapiens
maxDepth	3
name	p-Pellino:hp-IRAK1:TRAF6
producedByEvent	[Reaction:R-DME-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation - Drosophila melanogaster [Reaction:R-DME-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-975166
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-DME-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation [Reaction:R-DME-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation
(physicalEntity)	[CatalystActivity:10858705] ubiquitin-ubiquitin ligase activity of p-Pellino:hp-IRAK1:TRAF6 [endosome membrane] [CatalystActivity:10858708] protein kinase activity of TRAF6:hp-IRAK1:Pellino [endosome membrane]
(output)	[Reaction:R-DME-975139] IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation [Reaction:R-DME-975142] Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation
(inferredTo)	[Complex:R-HSA-975143] TRAF6:hp-IRAK1:Pellino [endosome membrane] [Complex:R-HSA-975166] p-Pellino:hp-IRAK1:TRAF6 [endosome membrane]