Reactome | CBL ubiquitinates PI3K

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10857696
displayName	CBL ubiquitinates PI3K
eventOf	[Pathway:R-DME-912631] Regulation of signaling by CBL - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-912627] CBL ubiquitinates PI3K - Homo sapiens
input	[Complex:R-DME-912647] FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Polymer:R-DME-912740] K48polyUb [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBL ubiquitinates PI3K
output	[Complex:R-DME-912799] FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-912627
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-912631] Regulation of signaling by CBL
(inferredTo)	[BlackBoxEvent:R-HSA-912627] CBL ubiquitinates PI3K