Reactome | Interferon alpha/beta signaling

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Interferon alpha/beta signaling Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912184
displayName	Interferon alpha/beta signaling
eventOf	[Pathway:R-DME-913531] Interferon Signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:383670] type I interferon-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DME-9710959] p-STAT1 dimer binds KPNA1 - Drosophila melanogaster [Reaction:R-DME-9710963] p-STAT1dimer:KPNA1 binds KPNB1 - Drosophila melanogaster [Reaction:R-DME-913529] Translocation of p-STAT1:p-STAT1 dimer to nucleus - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-909733] Interferon alpha/beta signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Interferon alpha/beta signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-909733
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-913531] Interferon Signaling
(hasEncapsulatedEvent)	[Pathway:R-DME-9833482] PKR-mediated signaling
(inferredTo)	[Pathway:R-HSA-909733] Interferon alpha/beta signaling

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