Reactome | Ubiquitin-dependent degradation of Cyclin D

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Ubiquitin-dependent degradation of Cyclin D Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910834
displayName	Ubiquitin-dependent degradation of Cyclin D
eventOf	[Pathway:R-DME-69242] S Phase - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:160432] proteasome-mediated ubiquitin-dependent protein catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-75822] Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm - Drosophila melanogaster [Reaction:R-DME-75823] Relocalization of nuclearly localized Cyclin D1 to the cytoplasm - Drosophila melanogaster [BlackBoxEvent:R-DME-75825] Proteasome mediated degradation of Cyclin D1 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-75815] Ubiquitin-dependent degradation of Cyclin D - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Ubiquitin-dependent degradation of Cyclin D
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-75815
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-69242] S Phase
(inferredTo)	[Pathway:R-HSA-75815] Ubiquitin-dependent degradation of Cyclin D

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