Reactome | ECHS1 hydrates methacrylyl-CoA

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ECHS1 hydrates methacrylyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10831162] enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10831164
displayName	ECHS1 hydrates methacrylyl-CoA
eventOf	[Pathway:R-DME-70895] Branched-chain amino acid catabolism - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-70881] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-70870] ECHS1 hydrates methacrylyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-70858] MACR-CoA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ECHS1 hydrates methacrylyl-CoA (2E)-2-methylpropenoyl-CoA + H2O => (S)-3-hydroxyisobutanoyl-CoA methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA
output	[SimpleEntity:R-ALL-71847] bHIB-CoA [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-70870
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-DME-70881] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
(inferredTo)	[Reaction:R-HSA-70870] ECHS1 hydrates methacrylyl-CoA

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