Reactome | oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]

Schema > Reaction > Entries

oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] Show undefined attributes

catalystActivity	[CatalystActivity:10830948] L-aspartate:2-oxoglutarate aminotransferase activity of PXLP-K259-GOT1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10830950
displayName	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]
eventOf	[Pathway:R-DME-8963693] Aspartate and asparagine metabolism - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] - Homo sapiens
input	[SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-76213] OA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1] L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate
output	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-70581
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8963693] Aspartate and asparagine metabolism
(precedingEvent)	[Reaction:R-DME-6787757] PXLP-K333-GADL1 decarboxylates acidic AAs
(inferredTo)	[Reaction:R-HSA-70581] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]

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