Reactome | AK4 phosphorylates (d)NMPs to (d)NDPs

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AK4 phosphorylates (d)NMPs to (d)NDPs Show undefined attributes

catalystActivity	[CatalystActivity:10886059] nucleoside monophosphate kinase activity of AK4 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10886061
displayName	AK4 phosphorylates (d)NMPs to (d)NDPs
eventOf	[Pathway:R-DME-499943] Interconversion of nucleotide di- and triphosphates - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6788798] AK4 phosphorylates (d)NMPs to (d)NDPs - Homo sapiens
input	[DefinedSet:R-ALL-6788802] (d)NMPs [mitochondrial matrix] [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	AK4 phosphorylates (d)NMPs to (d)NDPs AMP + ATP => 2 ADP dAMP + ATP => dADP + ADP CMP + ATP => CDP + ADP dCMP + ATP => dCDP + ADP
output	[DefinedSet:R-ALL-6788801] (d)NDPs [mitochondrial matrix] [SimpleEntity:R-ALL-113581] ADP [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6788798
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-499943] Interconversion of nucleotide di- and triphosphates
(inferredTo)	[Reaction:R-HSA-6788798] AK4 phosphorylates (d)NMPs to (d)NDPs

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