Reactome | Nucleotide exchange on RAB1

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Nucleotide exchange on RAB1 Show undefined attributes

catalystActivity	[CatalystActivity:10884128] guanyl-nucleotide exchange factor activity of COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle]
category	transition
compartment	[Compartment:13959] COPII-coated ER to Golgi transport vesicle
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10884130
displayName	Nucleotide exchange on RAB1
eventOf	[Pathway:R-DME-204005] COPII-mediated vesicle transport - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-5694418] RAB1:GTP binds USO1 and GORASP1:GOLGA2 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-5694409] Nucleotide exchange on RAB1 - Homo sapiens
input	[Complex:R-DME-5694334] COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Nucleotide exchange on RAB1
output	[Complex:R-DME-5694330] COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] [SimpleEntity:R-ALL-29420] GDP [cytosol]
precedingEvent	[Reaction:R-DME-5694439] COPII coat binds TRAPPCII and RAB1:GDP - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5694409
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-204005] COPII-mediated vesicle transport
(precedingEvent)	[Reaction:R-DME-5694418] RAB1:GTP binds USO1 and GORASP1:GOLGA2
(inferredTo)	[Reaction:R-HSA-5694409] Nucleotide exchange on RAB1