Reactome | phospho-tefu [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10882376] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DME-9006829] Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] - Drosophila melanogaster [Complex:R-DME-5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10881878
displayName	phospho-tefu [nucleoplasm]
endCoordinate	3056
hasModifiedResidue	[ModifiedResidue:10881876] O-phospho-L-serine at 1981 (in Homo sapiens) [ModifiedResidue:10881869] N6-acetyl-L-lysine at 3016 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-5693527] p-S1981,Ac-K3016-ATM [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-tefu p-S1981,Ac-K3016-ATM Q5EAK6
producedByEvent	[Reaction:R-DME-5682026] MRN bound to shortened telomeres activates ATM - Drosophila melanogaster [Reaction:R-DME-5693540] MRN activates ATM - Drosophila melanogaster
referenceEntity	[ReferenceGeneProduct:uniprot:Q5EAK6] UniProt:Q5EAK6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:56210] Drosophila melanogaster
stId	R-DME-5693527
startCoordinate	1

(output)	[Reaction:R-DME-5682026] MRN bound to shortened telomeres activates ATM [Reaction:R-DME-5693540] MRN activates ATM
(hasComponent)	[Complex:R-DME-9006829] Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] [Complex:R-DME-5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-DME-5682055] DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-DME-5684122] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
(physicalEntity)	[CatalystActivity:10882376] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
(activeUnit)	[CatalystActivity:10882198] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [CatalystActivity:10883772] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] [CatalystActivity:10882156] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] [CatalystActivity:10883786] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] [CatalystActivity:10883800] protein serine/threonine kinase activity of DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-5693527] p-S1981,Ac-K3016-ATM [nucleoplasm]