Reactome | K63polyUb [cytosol]

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K63polyUb [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-8948017] UBE2N:UBE2V1:K63polyUb [cytosol] - Drosophila melanogaster [Complex:R-DME-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] - Drosophila melanogaster [Complex:R-DME-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] - Drosophila melanogaster [Complex:R-DME-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] - Drosophila melanogaster
consumedByEvent	[BlackBoxEvent:R-DME-5696547] STAMBPL1 is a deubiquitinase - Drosophila melanogaster [Reaction:R-DME-5691431] PSMD14 cleaves K63-linked ubiquitin - Drosophila melanogaster [Reaction:R-DME-5688797] ATXN3 family cleave Ub chains - Drosophila melanogaster [Reaction:R-DME-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation - Drosophila melanogaster [Reaction:R-DME-937050] Pellino ubiquitinates hp-IRAK1 - Drosophila melanogaster [Reaction:R-DME-937050] Pellino ubiquitinates hp-IRAK1 - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10839589
displayName	K63polyUb [cytosol]
inDisease	false
inferredFrom	[Polymer:R-HSA-6783297] Short K63polyUb [cytosol] - Homo sapiens [Polymer:R-HSA-450152] K63polyUb [cytosol] - Homo sapiens
maxDepth	3
memberOf	[DefinedSet:R-DME-5689096] PolyUb [cytosol] - Drosophila melanogaster
name	K63polyUb
producedByEvent	[Reaction:R-DME-5688797] ATXN3 family cleave Ub chains - Drosophila melanogaster [Polymerisation:R-DME-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation - Drosophila melanogaster [Polymerisation:R-DME-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains - Drosophila melanogaster [Reaction:R-DME-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 - Drosophila melanogaster [Reaction:R-DME-8869506] TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 - Drosophila melanogaster [Reaction:R-DME-6781779] USP13 deubiquitinates BECN1,USP10 - Drosophila melanogaster [Reaction:R-DME-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG - Drosophila melanogaster
repeatedUnit	[DefinedSet:R-DME-450143] K63-Ub [cytosol]
schemaClass	Polymer
species	[Species:56210] Drosophila melanogaster
stId	R-DME-450152
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-DME-5690856] TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 [Reaction:R-DME-8869506] TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 [Reaction:R-DME-6781779] USP13 deubiquitinates BECN1,USP10 [Reaction:R-DME-5696627] CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [Reaction:R-DME-5688797] ATXN3 family cleave Ub chains [Polymerisation:R-DME-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation [Polymerisation:R-DME-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains
(input)	[BlackBoxEvent:R-DME-5696547] STAMBPL1 is a deubiquitinase [Reaction:R-DME-5691431] PSMD14 cleaves K63-linked ubiquitin [Reaction:R-DME-5688797] ATXN3 family cleave Ub chains [Reaction:R-DME-975122] Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation [Reaction:R-DME-937050] Pellino ubiquitinates hp-IRAK1
(inferredTo)	[Polymer:R-HSA-6783297] Short K63polyUb [cytosol] [Polymer:R-HSA-450152] K63polyUb [cytosol]
(hasComponent)	[Complex:R-DME-8948017] UBE2N:UBE2V1:K63polyUb [cytosol] [Complex:R-DME-937060] p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol]
(hasMember)	[DefinedSet:R-DME-5689096] PolyUb [cytosol]

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