Reactome | PER is phosphorylated by DCO

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PER is phosphorylated by DCO Show undefined attributes

authored	[InstanceEdit:432420] Williams, MG, 2009-08-13
catalystActivity	[CatalystActivity:208884] protein serine/threonine kinase activity of AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:432644] Williams, MG, 2009-08-14
dbId	432559
displayName	PER is phosphorylated by DCO
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-432553] Phosphorylation of PER and TIM - Drosophila melanogaster
figure	[Figure:901091] /figures/DrosCircClockD05.jpg
followingEvent	[Reaction:R-DME-432647] Phosphorylated PER binds to TIM - Drosophila melanogaster [BlackBoxEvent:R-DME-432411] SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination - Drosophila melanogaster [Reaction:R-DME-432556] Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO - Drosophila melanogaster
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-DME-432347] PER:DCO [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:432526] Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime [LiteratureReference:432446] The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock [LiteratureReference:538819] The F-box protein slimb controls the levels of clock proteins period and timeless
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PER is phosphorylated by DCO
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DME-881987] Phospho (multi-site 1) PER:DCO [cytosol]
precedingEvent	[Reaction:R-DME-538835] PER binds to DCO - Drosophila melanogaster [Reaction:R-DME-432556] Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:909536] Edery, I, 2010-07-06
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-432559
summation	[Summation:432451] Period (PER) is phosphorylated on between 15-20 individual s...

Referrals

(hasEvent)	[Pathway:R-DME-432553] Phosphorylation of PER and TIM
(precedingEvent)	[Reaction:R-DME-432647] Phosphorylated PER binds to TIM [BlackBoxEvent:R-DME-432411] SLMB binds phosphorylated cytosolic PER, facilitating its ubiquitination [Reaction:R-DME-432556] Cytosolic PP2A dephosphorylates phosphorylated PER complexed with DCO