PER is phosphorylated by DCO

Stable Identifier
R-DME-432559
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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PER is phosphorylated by DCO
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Period (PER) is phosphorylated on between 15-20 individual serine and threonine sites by Casein kinase 1epsilon orthologue, Discs Overgrown (DCO) aka Double-time (DBT). During the day, when light activated regulation of Timeless (TIM) occurs and its levels are low, phosphorylated PER is susceptible to supernumerary limbs (SLMB) mediated ubiquitination and degradation. Ser47 and possibly other phosphorylated residues nearby are key phospho-signals on PER mediating the binding of SLMB to PER.
Literature References
PubMed ID Title Journal Year
12432393 The F-box protein slimb controls the levels of clock proteins period and timeless

Grima, B, Lamouroux, A, Limbourg-Bouchon, B, Papin, C, Rouyer, F, Chélot, E

Nature 2002
18593878 The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock

Vanselow, JT, Edery, I, Kramer, A, Chiu, JC

Genes Dev 2008
12442174 Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime

Jiang, J, Edery, I, Ko, HW

Nature 2002
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol]

Physical Entity
AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2009-08-13)
Reviewed
Edery, I  (2010-07-06)
Created
Williams, MG  (2009-08-14)
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