Reactome | ROCK1,ROCK2 [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-9680444] ROCK1,ROCK2:ROCKi [cytosol] - Drosophila melanogaster [Complex:R-DME-422483] Activated ROCK:RhoA/B/C:GTP [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-3928576] RHOA:GTP binds ROCK, activating it - Drosophila melanogaster [Reaction:R-DME-9680443] ROCK1,2 bind ROCKi - Drosophila melanogaster [Reaction:R-DME-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2 - Drosophila melanogaster [Reaction:R-DME-419049] ROCK activation by RHO - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10850525
displayName	ROCK1,ROCK2 [cytosol]
hasMember	[EntityWithAccessionedSequence:R-DME-212509] ROCK1 [cytosol] - Drosophila melanogaster [DefinedSet:R-DME-419058-3] Homologues of ROCK2 [cytosol] - Drosophila melanogaster
inDisease	false
inferredFrom	[DefinedSet:R-HSA-419057] ROCK1,ROCK2 [cytosol] - Homo sapiens [DefinedSet:R-HSA-4687776] Activated ROCK1,ROCK2 [cytosol] - Homo sapiens
maxDepth	3
name	ROCK1,ROCK2
schemaClass	DefinedSet
species	[Species:56210] Drosophila melanogaster
stId	R-DME-419057

(input)	[Reaction:R-DME-3928576] RHOA:GTP binds ROCK, activating it [Reaction:R-DME-419049] ROCK activation by RHO [Reaction:R-DME-9680443] ROCK1,2 bind ROCKi [Reaction:R-DME-3928647] RHOA:GTP:Mg2+ binds ROCK1,ROCK2
(hasComponent)	[Complex:R-DME-9680444] ROCK1,ROCK2:ROCKi [cytosol] [Complex:R-DME-422483] Activated ROCK:RhoA/B/C:GTP [plasma membrane] [Complex:R-DME-5228987] RHOA:GTP:Mg2+:Activated ROCK1,ROCK2 [cytosol]
(inferredTo)	[DefinedSet:R-HSA-419057] ROCK1,ROCK2 [cytosol] [DefinedSet:R-HSA-4687776] Activated ROCK1,ROCK2 [cytosol]