Reactome | isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

Schema > Reaction > Entries

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ Show undefined attributes

catalystActivity	[CatalystActivity:10849297] isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10849299
displayName	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
eventOf	[Pathway:R-DME-389542] NADPH regeneration - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-389540] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Homo sapiens
input	[SimpleEntity:R-ALL-389545] ISCIT [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
output	[SimpleEntity:R-ALL-29406] 2OG [cytosol] [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-DME-5690911] ACO1:4Fe-4S isomerises CIT to ISCIT - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-389540
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-389542] NADPH regeneration
(inferredTo)	[Reaction:R-HSA-389540] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

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