Reactome | Regulation of HSF1-mediated heat shock response

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Regulation of HSF1-mediated heat shock response Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10912660
displayName	Regulation of HSF1-mediated heat shock response
eventOf	[Pathway:R-DME-3371556] Cellular response to heat stress - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133281] regulation of cellular response to heat
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-3371531] Constitutive phosphorylation by pERK1/2 - Drosophila melanogaster [Reaction:R-DME-3371435] Constitutive phosphorylation by GSK3 - Drosophila melanogaster [Reaction:R-DME-4793925] p-S303,307-HSF1 binds YWHAE (14-3-3) - Drosophila melanogaster [Reaction:R-DME-4793911] MAPKAPK2 phosphorylates HSF1 - Drosophila melanogaster [Reaction:R-DME-5251959] HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol - Drosophila melanogaster [Reaction:R-DME-5252079] HSP110s exchange ATP for ADP on HSP70s:ADP - Drosophila melanogaster [Reaction:R-DME-5251942] Hikeshi binds HSP70s:ATP - Drosophila melanogaster [Reaction:R-DME-5252041] NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm - Drosophila melanogaster [Reaction:R-DME-5251955] HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-3371453] Regulation of HSF1-mediated heat shock response - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of HSF1-mediated heat shock response
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-3371453
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-3371556] Cellular response to heat stress
(inferredTo)	[Pathway:R-HSA-3371453] Regulation of HSF1-mediated heat shock response

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