Reactome | SLC17A5 exports GlcA from the lysosome to the cytosol

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SLC17A5 exports GlcA from the lysosome to the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10870245] glucuronate transmembrane transporter activity of SLC17A5 [lysosomal membrane]
category	transition
compartment	[Compartment:17938] lysosomal membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10870247
displayName	SLC17A5 exports GlcA from the lysosome to the cytosol
eventOf	[Pathway:R-DME-2160916] Hyaluronan degradation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2455403] carbohydrate derivative transport
inferredFrom	[Reaction:R-HSA-2162229] SLC17A5 exports GlcA from the lysosome to the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-1678868] GlcA [lysosomal lumen] [SimpleEntity:R-ALL-428040] H+ [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC17A5 exports GlcA from the lysosome to the cytosol
output	[SimpleEntity:R-ALL-2162232] GlcA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-DME-2162226] GUSB tetramer hydrolyzes GlcA-?1,3-GlcNAc - Drosophila melanogaster [Reaction:R-DME-2162227] GUSB tetramer hydrolyses (HA)2 - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2162229
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-2160916] Hyaluronan degradation
(inferredTo)	[Reaction:R-HSA-2162229] SLC17A5 exports GlcA from the lysosome to the cytosol

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