Reactome | Phosphorylated CACT is degraded in the cytosol

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Phosphorylated CACT is degraded in the cytosol Show undefined attributes

authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
catalystActivity	[CatalystActivity:208900] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:214841] Williams, MG, 2008-02-26 12:28:44
dbId	214871
displayName	Phosphorylated CACT is degraded in the cytosol
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209406] Degradation of NF-kappa-B inhibitor, CACT - Drosophila melanogaster
figure	[Figure:358168] /figures/DrosTollImdC21.jpg
followingEvent	[Reaction:R-DME-209295] Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus - Drosophila melanogaster
input	[Complex:R-DME-214741] Phospho DL/DIF dimer:Phospho CACT [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:214877] Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses [LiteratureReference:208075] A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo [LiteratureReference:214855] Cactus protein degradation mediates Drosophila dorsal-ventral signaling [LiteratureReference:214846] A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila [LiteratureReference:214843] In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila [LiteratureReference:208375] Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated CACT is degraded in the cytosol
output	[DefinedSet:R-DME-214728] Phospho DL/DIF dimer [cytosol]
precedingEvent	[Reaction:R-DME-214864] Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' - Drosophila melanogaster [Reaction:R-DME-214847] Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-214871
summation	[Summation:214264] In humans, the Cactus (CACT) orthologue IkappaB is polyubiqu...

Referrals

(hasEvent)	[Pathway:R-DME-209406] Degradation of NF-kappa-B inhibitor, CACT
(precedingEvent)	[Reaction:R-DME-209295] Phosphorylated DL/DIF dimer transports from the cytosol to the nucleus