Reactome | Phosphorylated CACT is degraded in the cytosol

Phosphorylated CACT is degraded in the cytosol

Stable Identifier

R-DME-214871

Type

Reaction [omitted]

Species

Drosophila melanogaster

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Phosphorylated CACT is degraded in the cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In humans, the Cactus (CACT) orthologue IkappaB is polyubiquitinated by the beta-TrCP E3 ubiquitin ligase containing complex. This marks it for degradation by the 26S proteosome. It is believed that CACT is degraded in a similar manner, however, a Drosophila E3 ubiquitin ligase that acts in the Toll pathway has yet to be identified. The obvious candidate, the closest beta-TrCP orthologue Slimb (SLMB) has produced contradictory evidence on whether it participates in the Toll pathway (Spencer et al., 1999; Leulier et al., 2003).

Literature References

PubMed ID	Title	Journal	Year
12973300	Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses Leulier, F, Marchal, C, Miletich, I, Limbourg-Bouchon, B, Benarous, R, Lemaitre, B	EMBO Rep	2003
9025065	A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila Bergmann, A, Stein, D, Geisler, R, Hagenmaier, S, Schmid, B, Fernandez, N, Schnell, B, Nüsslein-Volhard, C	Mech Dev	1996
9553105	In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila Nicolas, E, Reichhart, JM, Hoffmann, JA, Lemaitre, B	J Biol Chem	1998
8948598	A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo Reach, M, Galindo, RL, Towb, P, Allen, JL, Karin, M, Wasserman, SA	Dev Biol	1996
9990853	Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP Spencer, E, Jiang, J, Chen, ZJ	Genes Dev	1999
7705656	Cactus protein degradation mediates Drosophila dorsal-ventral signaling Belvin, MP, Jin, Y, Anderson, KV	Genes Dev	1995