Reactome | Formation of the 'scaffold complex'

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Formation of the 'scaffold complex' Show undefined attributes

authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205626] Williams, MG, 2006-12-08 11:30:45
dbId	209331
displayName	Formation of the 'scaffold complex'
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209159] Assembly of the CI containing complexes - Drosophila melanogaster
figure	[Figure:216258] /figures/DrosHHB05.jpg
followingEvent	[Pathway:R-DME-209190] Phosphorylation of CI - Drosophila melanogaster [Reaction:R-DME-209196] Phosphorylation of CI by PKA-C1 - Drosophila melanogaster
input	[EntityWithAccessionedSequence:R-DME-206046] CI [cytosol] [EntityWithAccessionedSequence:R-DME-206210] CKIalpha [cytosol] [EntityWithAccessionedSequence:R-DME-205832] COS [cytosol] [EntityWithAccessionedSequence:R-DME-205729] DCO [cytosol] [EntityWithAccessionedSequence:R-DME-205872] FU [cytosol] [EntityWithAccessionedSequence:R-DME-205931] PKA-C1 [cytosol] [EntityWithAccessionedSequence:R-DME-205716] SGG [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208042] Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2 [LiteratureReference:208101] Identification of a tetrameric hedgehog signaling complex [LiteratureReference:208356] Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway [LiteratureReference:208076] Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms [LiteratureReference:208363] Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus [LiteratureReference:208191] Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 [LiteratureReference:208158] Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus [LiteratureReference:208279] Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of the 'scaffold complex'
output	[Complex:R-DME-206721] COS:CI:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol]
precedingEvent	[BlackBoxEvent:R-DME-209278] Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209331
summation	[Summation:206318] The kinesin-related protein, Costal2 (COS), forms a microtub...

Referrals

(precedingEvent)	[Pathway:R-DME-209190] Phosphorylation of CI [Reaction:R-DME-209196] Phosphorylation of CI by PKA-C1
(hasEvent)	[Pathway:R-DME-209159] Assembly of the CI containing complexes

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