Reactome | Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex

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Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex Show undefined attributes

authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
catalystActivity	[CatalystActivity:208900] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205626] Williams, MG, 2006-12-08 11:30:45
dbId	209278
displayName	Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209360] Ubiquitination and proteolysis of phosphorylated CI - Drosophila melanogaster
figure	[Figure:216239] /figures/DrosHHB12.jpg
followingEvent	[Reaction:R-DME-209370] CI75 transports from the cytosol to the nucleus - Drosophila melanogaster [Reaction:R-DME-209331] Formation of the 'scaffold complex' - Drosophila melanogaster [Reaction:R-DME-209224] SLMB binds to and ubiquitinates phosphorylated CI - Drosophila melanogaster
input	[Complex:R-DME-207011] SLMB:SKPA:LIN19:ROC1A:EFF:COS:Phospho (16 sites) CI:UBI-P63E:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208320] Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression [LiteratureReference:208302] Degrading Ci: who is Cul-pable? [LiteratureReference:208353] Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor [LiteratureReference:208132] Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus [LiteratureReference:216208] A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-kappaB
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex
output	[EntityWithAccessionedSequence:R-DME-206171] CI75 [cytosol] [Complex:R-DME-206900] COS:FU:PKA-C1:SGG:CKIalpha:DCO [cytosol] [Complex:R-DME-206788] SLMB:SKPA:LIN19:ROC1A:EFF [cytosol] [DefinedSet:R-DME-206204] UBI-P63E [cytosol]
precedingEvent	[Reaction:R-DME-209224] SLMB binds to and ubiquitinates phosphorylated CI - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
schemaClass	BlackBoxEvent
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209278
summation	[Summation:206407] Ubiquitinated and phosphorylated Cubitus Interruptus (CI) is...

Referrals

(precedingEvent)	[Reaction:R-DME-209370] CI75 transports from the cytosol to the nucleus [Reaction:R-DME-209224] SLMB binds to and ubiquitinates phosphorylated CI [Reaction:R-DME-209331] Formation of the 'scaffold complex'
(hasEvent)	[Pathway:R-DME-209360] Ubiquitination and proteolysis of phosphorylated CI

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