Reactome | Autocleavage of HH

Schema > Reaction > Entries

authored	[InstanceEdit:386946] Williams, MG, 2006-12-07 16:49:12
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205626] Williams, MG, 2006-12-08 11:30:45
dbId	209313
displayName	Autocleavage of HH
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209471] Formation and transport of the N-HH ligand - Drosophila melanogaster
figure	[Figure:216240] /figures/DrosHHB01.jpg
followingEvent	[Reaction:R-DME-209357] N-HH is palmitoylated by RASP - Drosophila melanogaster
input	[SimpleEntity:R-ALL-176478] CHOL [cytosol] [EntityWithAccessionedSequence:R-DME-205973] HH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208280] Cholesterol modification of hedgehog signaling proteins in animal development [LiteratureReference:216127] Novel lipid modifications of secreted protein signals
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autocleavage of HH
output	[EntityWithAccessionedSequence:R-DME-206216] C-HH [cytosol] [EntityWithAccessionedSequence:R-DME-206215] N-HH [cytosol]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386945] Kalderon, D, 2008-03-17 11:00:25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209313
summation	[Summation:206442] The autoprocessing event results in cleavage of Hedgehog (HH...

(precedingEvent)	[Reaction:R-DME-209357] N-HH is palmitoylated by RASP
(hasEvent)	[Pathway:R-DME-209471] Formation and transport of the N-HH ligand

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