Autocleavage of HH

Stable Identifier
R-DME-209313
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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The autoprocessing event results in cleavage of Hedgehog (HH) between Gly207 and Cys208, coupled to the covalent addition of cholesterol to Gly207 via an ester linkage to form N-HH.

Literature References
PubMed ID Title Journal Year
8824192 Cholesterol modification of hedgehog signaling proteins in animal development

Porter, JA, Young, KE, Beachy, PA

Science 1996
15189162 Novel lipid modifications of secreted protein signals

Mann, RK, Beachy, PA

Annu Rev Biochem 2004
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