Reactome | ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane

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ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane Show undefined attributes

authored	[InstanceEdit:386948] Williams, MG, 2007-07-11 16:49:12
category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:205654] Williams, MG, 2007-07-12 09:20:19
dbId	209141
displayName	ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209442] Formation of the trans-membrane 'signalling complex' - Drosophila melanogaster
figure	[Figure:358188] /figures/DrosTollImdC06.jpg
followingEvent	[Reaction:R-DME-209076] SPZ dimer bound TL dimerises at the plasma membrane - Drosophila melanogaster
input	[Complex:R-DME-206793] ProSPZ:SPZ dimer [extracellular region] [EntityWithAccessionedSequence:R-DME-206218] TL [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208301] Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand [LiteratureReference:358180] Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand Sp�tzle
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane
output	2 × [EntityWithAccessionedSequence:R-DME-205949] ProSPZ [extracellular region] [Complex:R-DME-206655] SPZ dimer:TL [plasma membrane]
precedingEvent	[Reaction:R-DME-209130] Full-length SPZ dimer is cleaved by EA/SPE serine protease - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209141
summation	[Summation:206469] On binding to the Toll (TL) receptor ectodomain, Spatzle (SP...

Referrals

(precedingEvent)	[Reaction:R-DME-209076] SPZ dimer bound TL dimerises at the plasma membrane
(hasEvent)	[Pathway:R-DME-209442] Formation of the trans-membrane 'signalling complex'

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