Reactome | Formation of the 'destruction complex'

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Formation of the 'destruction complex' Show undefined attributes

authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205630] Williams, MG, 2006-06-28 10:48:14
dbId	209133
displayName	Formation of the 'destruction complex'
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209413] Assembly of the 'destruction complex' - Drosophila melanogaster
figure	[Figure:208806] /figures/BDrosWing01.jpg
followingEvent	[Pathway:R-DME-209155] Phosphorylation of AXN and APC - Drosophila melanogaster [Reaction:R-DME-209143] Phosphorylation of AXN and APC by DCO - Drosophila melanogaster
inferredFrom	[Reaction:R-MMU-209148] Murine CKIalpha binds to Murine Axin1 - Mus musculus [Reaction:R-MMU-209059] Murine CKIepsilon binds to Murine Axin1 - Mus musculus
input	[DefinedSet:R-DME-206581] APC [cytosol] [EntityWithAccessionedSequence:R-DME-206017] AXN [cytosol] [EntityWithAccessionedSequence:R-DME-206210] CKIalpha [cytosol] [EntityWithAccessionedSequence:R-DME-205729] DCO [cytosol] [Complex:R-DME-206938] PP2A [cytosol] [EntityWithAccessionedSequence:R-DME-205716] SGG [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:208233] A Drosophila Axin homolog, Daxin, inhibits Wnt signaling [LiteratureReference:208172] Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin [LiteratureReference:208185] Biochemical characterization of the Drosophila axin protein [LiteratureReference:208070] A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of the 'destruction complex'
output	[Complex:R-DME-206741] AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol]
precedingEvent	[Reaction:R-DME-209081] Disassembly of the destabilised 'destruction complex' - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209133
summation	[Summation:206413] The 'destruction complex' is formed from the large scaffoldi...

Referrals

(hasEvent)	[Pathway:R-DME-209413] Assembly of the 'destruction complex'
(precedingEvent)	[Pathway:R-DME-209155] Phosphorylation of AXN and APC [Reaction:R-DME-209143] Phosphorylation of AXN and APC by DCO
(inferredTo)	[Reaction:R-MMU-209148] Murine CKIalpha binds to Murine Axin1 [Reaction:R-MMU-209059] Murine CKIepsilon binds to Murine Axin1