The 'destruction complex' is formed from the large scaffoldi...

created [InstanceEdit:205613] Williams, MG, 2006-07-20 14:47:06
dbId 206413
displayName The 'destruction complex' is formed from the large scaffoldi...
modified [InstanceEdit:210817] Williams, MG, 2008-01-16 16:52:43
schemaClass Summation
text The 'destruction complex' is formed from the large scaffolding proteins Axin (AXN) and APC (APC/APC2). This enables regulating molecules such as the kinases, CKIalpha, DCO, and Shaggy (SGG) and the phosphatase, PP2A to be held together in close proximity where they can regulate the phosphorylation of the scaffolding molecules and cytoplasmic Armadillo (ARM). The protein serine/threonine phosphatase PP2A is made up of the regulatory subunit A, PP2A-29B; the regulatory subunit B, Twins (TWS); and the catalytic subunit C, Microtubule star (MTS).
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