Reactome | ARM binds to APC and AXN in the 'destruction complex'

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ARM binds to APC and AXN in the 'destruction complex' Show undefined attributes

authored	[InstanceEdit:386950] Williams, MG, 2006-07-26 16:49:12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:205630] Williams, MG, 2006-06-28 10:48:14
dbId	209097
displayName	ARM binds to APC and AXN in the 'destruction complex'
edited	[InstanceEdit:5490376] Williams, MG, 2014-05-20
eventOf	[Pathway:R-DME-209413] Assembly of the 'destruction complex' - Drosophila melanogaster
figure	[Figure:208625] /figures/BDrosWing06.jpg
followingEvent	[Pathway:R-DME-209396] Phosphorylation of ARM - Drosophila melanogaster [Reaction:R-DME-209134] Phosphorylation of ARM by CKIalpha - Drosophila melanogaster
input	[EntityWithAccessionedSequence:R-DME-205774] ARM [cytosol] [Complex:R-DME-206602] Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208070] A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo [LiteratureReference:208233] A Drosophila Axin homolog, Daxin, inhibits Wnt signaling [LiteratureReference:208172] Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ARM binds to APC and AXN in the 'destruction complex'
output	[Complex:R-DME-206666] ARM:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [cytosol]
precedingEvent	[Reaction:R-DME-209094] Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex' - Drosophila melanogaster [Reaction:R-DME-209082] Further phosphorylation of APC by SGG - Drosophila melanogaster [Reaction:R-DME-209112] Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM - Drosophila melanogaster [Reaction:R-DME-209049] Phosphorylation of AXN and APC by SGG - Drosophila melanogaster
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:386952] Nusse, Roel, 2008-01-19
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209097
summation	[Summation:206379] Phosphorylated APC (APC/APC2) and Axin (AXN) are able to bin...

Referrals

(hasEvent)	[Pathway:R-DME-209413] Assembly of the 'destruction complex'
(precedingEvent)	[Pathway:R-DME-209396] Phosphorylation of ARM [Reaction:R-DME-209134] Phosphorylation of ARM by CKIalpha