Reactome | Pten [cytosol]

Schema > EntityWithAccessionedSequence > Entries

Pten [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10843242] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol] [CatalystActivity:10864322] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-DME-8847960] PTEN:p-Y387-FRK [cytosol] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-8948775] MKRN1 polyubiquitinates PTEN - Drosophila melanogaster [Reaction:R-DME-8948800] TNKS and TNKS2 PARylate PTEN - Drosophila melanogaster [Reaction:R-DME-8850945] Casein kinase II phosphorylates PTEN - Drosophila melanogaster [Reaction:R-DME-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN - Drosophila melanogaster [Reaction:R-DME-6807106] PTEN undergoes monoubiquitination - Drosophila melanogaster [Reaction:R-DME-8847968] PTEN binds FRK - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10843241
displayName	Pten [cytosol]
endCoordinate	403
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol] - Homo sapiens
maxDepth	1
name	Pten PTEN Q7KMQ6
producedByEvent	[Reaction:R-DME-6807206] USP13 and OTUD3 deubiquitinate PTEN - Drosophila melanogaster [Reaction:R-DME-6807126] Deubiquitinated PTEN translocates to the cytosol - Drosophila melanogaster
referenceEntity	[ReferenceGeneProduct:uniprot:Q7KMQ6] UniProt:Q7KMQ6 Pten
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:56210] Drosophila melanogaster
stId	R-DME-199420
startCoordinate	2

Referrals

(input)	[Reaction:R-DME-8948775] MKRN1 polyubiquitinates PTEN [Reaction:R-DME-8948800] TNKS and TNKS2 PARylate PTEN [Reaction:R-DME-8847968] PTEN binds FRK [Reaction:R-DME-8850945] Casein kinase II phosphorylates PTEN [Reaction:R-DME-6807134] NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN [Reaction:R-DME-6807106] PTEN undergoes monoubiquitination
(hasComponent)	[Complex:R-DME-8847960] PTEN:p-Y387-FRK [cytosol] [Complex:R-DME-199426] PTEN:Mg2+ [cytosol]
(output)	[Reaction:R-DME-6807206] USP13 and OTUD3 deubiquitinate PTEN [Reaction:R-DME-6807126] Deubiquitinated PTEN translocates to the cytosol
(physicalEntity)	[CatalystActivity:10843242] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol] [CatalystActivity:10864322] phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of PTEN [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol]

© 2026 Reactome

Cite Us!