Reactome | phospho-foxo [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-DME-211178] Phosphorylated FOXO1A is excluded from the nucleus - Drosophila melanogaster [BlackBoxEvent:R-DME-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10843212
displayName	phospho-foxo [nucleoplasm]
endCoordinate	655
hasModifiedResidue	[ModifiedResidue:10843208] O-phospho-L-threonine at 24 (in Homo sapiens) [ModifiedResidue:10843209] O-phospho-L-serine at 256 (in Homo sapiens) [ModifiedResidue:10843210] O-phospho-L-serine at 319 (in Homo sapiens)
inDisease	false
inferredFrom	[DefinedSet:R-HSA-199269] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm] - Homo sapiens [CandidateSet:R-HSA-9614997] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-199306] p-T24,S256,S319-FOXO1 [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-foxo p-T24,S256,S319-FOXO1 Q95V55
producedByEvent	[Reaction:R-DME-211164] AKT phosphorylates FOXO1A - Drosophila melanogaster [Reaction:R-DME-199299] AKT phosphorylates FOXO transcription factors - Drosophila melanogaster
referenceEntity	[ReferenceGeneProduct:uniprot:Q95V55] UniProt:Q95V55 foxo
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:56210] Drosophila melanogaster
stId	R-DME-199306
startCoordinate	1

(input)	[Reaction:R-DME-211178] Phosphorylated FOXO1A is excluded from the nucleus [BlackBoxEvent:R-DME-9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol
(output)	[Reaction:R-DME-211164] AKT phosphorylates FOXO1A [Reaction:R-DME-199299] AKT phosphorylates FOXO transcription factors
(inferredTo)	[DefinedSet:R-HSA-199269] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [nucleoplasm] [CandidateSet:R-HSA-9614997] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-199306] p-T24,S256,S319-FOXO1 [nucleoplasm]