Reactome | ALAS condenses SUCC-CoA and Gly to form dALA

Schema > Reaction > Entries

ALAS condenses SUCC-CoA and Gly to form dALA Show undefined attributes

catalystActivity	[CatalystActivity:10667514] 5-aminolevulinate synthase activity of ALAS1,2 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10667516
displayName	ALAS condenses SUCC-CoA and Gly to form dALA
eventOf	[Pathway:R-DME-189451] Heme biosynthesis - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-189442] ALAS condenses SUCC-CoA and Gly to form dALA - Homo sapiens
input	[SimpleEntity:R-ALL-159549] Gly [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-70958] SUCC-CoA [mitochondrial matrix]
isInDisease	false
isInferred	true
name	ALAS condenses SUCC-CoA and Gly to form dALA glycine + H(+) + succinyl-CoA => 5-aminolevulinate + CO2 + CoA Succinyl CoA and glycine condense to form 5-aminolevulinate (ALA)
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-189466] dALA [mitochondrial matrix]
regulatedBy	[NegativeRegulation:R-HSA-189417] Negative regulation by 'heme [mitochondrial matrix]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-189442
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-189451] Heme biosynthesis
(inferredTo)	[Reaction:R-HSA-189442] ALAS condenses SUCC-CoA and Gly to form dALA

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