Reactome | Association of Rb with Cyclin E:Cdk2 complexes

Schema > Reaction > Entries

Association of Rb with Cyclin E:Cdk2 complexes Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10841354
displayName	Association of Rb with Cyclin E:Cdk2 complexes
eventOf	[Pathway:R-DME-69202] Cyclin E associated events during G1/S transition - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-188390] Cyclin E:CDK2-mediated phosphorylation of RB1 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-188386] Association of Rb with Cyclin E:Cdk2 complexes - Homo sapiens
input	[Complex:R-DME-188362] Cyclin E:p-T160-CDK2 [nucleoplasm] [DefinedSet:R-DME-9687348] monophosphorylated RB1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Association of Rb with Cyclin E:Cdk2 complexes
output	[Complex:R-DME-188373] CCNE:p-T160-CDK2:hypophosphorylated RB1 [nucleoplasm]
precedingEvent	[Reaction:R-DME-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Drosophila melanogaster [Reaction:R-DME-69227] Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-188386
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-69202] Cyclin E associated events during G1/S transition
(precedingEvent)	[Reaction:R-DME-188390] Cyclin E:CDK2-mediated phosphorylation of RB1
(inferredTo)	[Reaction:R-HSA-188386] Association of Rb with Cyclin E:Cdk2 complexes

Cite Us!