Reactome | Intrinsic Pathway for Apoptosis

Schema > Pathway > Entries

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10911078
displayName	Intrinsic Pathway for Apoptosis
eventOf	[Pathway:R-DME-109581] Apoptosis - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133500] intrinsic apoptotic signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DME-111471] Apoptotic factor-mediated response - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-109606] Intrinsic Pathway for Apoptosis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	Intrinsic Pathway for Apoptosis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-109606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEncapsulatedEvent)	[Pathway:R-DME-1257604] PIP3 activates AKT signaling [Pathway:R-DME-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-DME-2559585] Oncogene Induced Senescence [Pathway:R-DME-6791312] TP53 Regulates Transcription of Cell Cycle Genes [Pathway:R-DME-5633008] TP53 Regulates Transcription of Cell Death Genes [Pathway:R-DME-2559580] Oxidative Stress Induced Senescence [Pathway:R-DME-5620971] Pyroptosis
(hasEvent)	[Pathway:R-DME-109581] Apoptosis
(inferredTo)	[Pathway:R-HSA-109606] Intrinsic Pathway for Apoptosis