Reactome | p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]

Schema > DefinedSet > Entries

catalystActivities	[CatalystActivity:10997792] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	10997791
displayName	p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
hasMember	[DefinedSet:R-DDI-9756822] p-T177-CDK6:CCND [nucleoplasm] - Dictyostelium discoideum [DefinedSet:R-DDI-9756821] p-T172-CDK4:CCND [nucleoplasm] - Dictyostelium discoideum
inDisease	false
inferredFrom	[CandidateSet:R-HSA-8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] - Homo sapiens
maxDepth	5
name	p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B)
negativelyRegulates	[NegativeRegulation:11042954] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'
producedByEvent	[Reaction:R-DDI-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Dictyostelium discoideum
schemaClass	DefinedSet
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-8949896

(regulator)	[NegativeRegulation:11042954] Negative regulation by 'p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]'
(physicalEntity)	[CatalystActivity:10997792] cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]
(output)	[Reaction:R-DDI-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6
(inferredTo)	[CandidateSet:R-HSA-8949896] p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]

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