Reactome | The NLRP3 inflammasome

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050068
displayName	The NLRP3 inflammasome
eventOf	[Pathway:R-DDI-622312] Inflammasomes - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DDI-877187] P2X7 mediates loss of intracellular K+ - Dictyostelium discoideum [Reaction:R-DDI-874087] SGT1 binds HSP90 - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-844456] The NLRP3 inflammasome - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	The NLRP3 inflammasome
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-844456
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DDI-622312] Inflammasomes
(inferredTo)	[Pathway:R-HSA-844456] The NLRP3 inflammasome

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