Reactome | Pyrophosphate hydrolysis

Schema > Pathway > Entries

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049032
displayName	Pyrophosphate hydrolysis
eventOf	[TopLevelPathway:R-DDI-1430728] Metabolism - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:449995] diphosphate metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DDI-449937] pyrophosphate + H2O => 2 orthophosphate [mitochondrial] - Dictyostelium discoideum [Reaction:R-DDI-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-71737] Pyrophosphate hydrolysis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Pyrophosphate hydrolysis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-71737
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[TopLevelPathway:R-DDI-1430728] Metabolism
(hasEncapsulatedEvent)	[Pathway:R-DDI-8956320] Nucleotide biosynthesis
(inferredTo)	[Pathway:R-HSA-71737] Pyrophosphate hydrolysis

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