Reactome | Degradation of PCSK9:LDLR:Clathrin-coated vesicle

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Degradation of PCSK9:LDLR:Clathrin-coated vesicle Show undefined attributes

category	omitted
compartment	[Compartment:1660541] endolysosome membrane [Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11031018
displayName	Degradation of PCSK9:LDLR:Clathrin-coated vesicle
eventOf	[Pathway:R-DDI-8964038] LDL clearance - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-6784738] Degradation of PCSK9:LDLR:Clathrin-coated vesicle - Homo sapiens
input	[Complex:R-DDI-6784728] PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Degradation of PCSK9:LDLR:Clathrin-coated vesicle
output	[Complex:R-DDI-2130671] Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-DDI-6784729] PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-6784738
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-8964038] LDL clearance
(inferredTo)	[BlackBoxEvent:R-HSA-6784738] Degradation of PCSK9:LDLR:Clathrin-coated vesicle

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