Reactome | PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome

Schema > Reaction > Entries

PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome Show undefined attributes

category	transition
compartment	[Compartment:1660541] endolysosome membrane [Compartment:876] plasma membrane
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11031016
displayName	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome
eventOf	[Pathway:R-DDI-8964038] LDL clearance - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-DDI-6784738] Degradation of PCSK9:LDLR:Clathrin-coated vesicle - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-6784729] PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome - Homo sapiens
input	[Complex:R-DDI-6784733] PCSK9:LDLR:Clathrin:AP2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome
output	[Complex:R-DDI-6784728] PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-6784729
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-8964038] LDL clearance
(precedingEvent)	[BlackBoxEvent:R-DDI-6784738] Degradation of PCSK9:LDLR:Clathrin-coated vesicle
(inferredTo)	[Reaction:R-HSA-6784729] PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome

Cite Us!