Reactome | ESD dimer hydrolyses S-FGSH to GSH

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ESD dimer hydrolyses S-FGSH to GSH Show undefined attributes

catalystActivity	[CatalystActivity:11029950] S-formylglutathione hydrolase activity of ESD dimer [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11029952
displayName	ESD dimer hydrolyses S-FGSH to GSH
eventOf	[Pathway:R-DDI-156590] Glutathione conjugation - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5693724] ESD dimer hydrolyses S-FGSH to GSH - Homo sapiens
input	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-5693723] S-FGSH [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	ESD dimer hydrolyses S-FGSH to GSH
output	[SimpleEntity:R-ALL-194712] formate [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-158543] GSH [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5693724
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-156590] Glutathione conjugation
(inferredTo)	[Reaction:R-HSA-5693724] ESD dimer hydrolyses S-FGSH to GSH

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