Reactome | Nuclear DUSPs dephosphorylate MAPKs

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Nuclear DUSPs dephosphorylate MAPKs Show undefined attributes

catalystActivity	[CatalystActivity:11026520] protein tyrosine/serine/threonine phosphatase activity of nuclear MAPK DUSPs [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11026522
displayName	Nuclear DUSPs dephosphorylate MAPKs
eventOf	[Pathway:R-DDI-112409] RAF-independent MAPK1/3 activation - Dictyostelium discoideum [Pathway:R-DDI-5675221] Negative regulation of MAPK pathway - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5675373] Nuclear DUSPs dephosphorylate MAPKs - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-DDI-5674341] p-T,Y MAPK monomers and dimers [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Nuclear DUSPs dephosphorylate MAPKs
output	[DefinedSet:R-DDI-5675363] MAPK monomers and dimers [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-DDI-5674387] Phosphorylated MAPKs translocate into the nucleus - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5675373
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5675221] Negative regulation of MAPK pathway [Pathway:R-DDI-112409] RAF-independent MAPK1/3 activation
(inferredTo)	[Reaction:R-HSA-5675373] Nuclear DUSPs dephosphorylate MAPKs