Reactome | Phosphorylated MAPKs translocate into the nucleus

Schema > BlackBoxEvent > Entries

Phosphorylated MAPKs translocate into the nucleus Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11026431
displayName	Phosphorylated MAPKs translocate into the nucleus
eventOf	[Pathway:R-DDI-112409] RAF-independent MAPK1/3 activation - Dictyostelium discoideum [Pathway:R-DDI-5673001] RAF/MAP kinase cascade - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-5675373] Nuclear DUSPs dephosphorylate MAPKs - Dictyostelium discoideum [Reaction:R-DDI-198756] ERK1/2 phosphorylates MSK1 - Dictyostelium discoideum [Reaction:R-DDI-198746] ERK1/2/5 activate RSK1/2/3 - Dictyostelium discoideum
inferredFrom	[BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus - Homo sapiens
input	[DefinedSet:R-DDI-5674340] p-T,Y MAPK monomers and dimers [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated MAPKs translocate into the nucleus
output	[DefinedSet:R-DDI-5674341] p-T,Y MAPK monomers and dimers [nucleoplasm]
precedingEvent	[Reaction:R-DDI-5674385] p-T,Y MAPKs dimerize - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-5674387
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-5673001] RAF/MAP kinase cascade [Pathway:R-DDI-112409] RAF-independent MAPK1/3 activation
(precedingEvent)	[Reaction:R-DDI-5675373] Nuclear DUSPs dephosphorylate MAPKs [Reaction:R-DDI-198746] ERK1/2/5 activate RSK1/2/3 [Reaction:R-DDI-198756] ERK1/2 phosphorylates MSK1
(inferredTo)	[BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus