Reactome | HDAC8 deacetylates histones

Schema > Reaction > Entries

HDAC8 deacetylates histones Show undefined attributes

catalystActivity	[CatalystActivity:11021948] histone deacetylase activity of HDAC8 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11021950
displayName	HDAC8 deacetylates histones
eventOf	[Pathway:R-DDI-3214815] HDACs deacetylate histones - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3782637] HDAC8 deacetylates histones - Homo sapiens
input	[Complex:R-DDI-4663858] Acetylated core histone octamer [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	HDAC8 deacetylates histones
output	[SimpleEntity:R-ALL-5566518] acetate [nucleoplasm] [Complex:R-DDI-4657034] Core histone octamer [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-3782637
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-3214815] HDACs deacetylate histones
(inferredTo)	[Reaction:R-HSA-3782637] HDAC8 deacetylates histones

Cite Us!