Reactome | HS-GAG degradation

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HS-GAG degradation Show undefined attributes

created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11050242
displayName	HS-GAG degradation
eventOf	[Pathway:R-DDI-1638091] Heparan sulfate/heparin (HS-GAG) metabolism - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21602] heparan sulfate proteoglycan catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-DDI-1678716] IDUA cleaves iduronate from HS chain - Dictyostelium discoideum [Reaction:R-DDI-1678660] HGSNAT oligomer acetylates Heparan sulfate chain(3) - Dictyostelium discoideum [Reaction:R-DDI-1678742] NAGLU hydrolyses Heparan sulfate chain(4) - Dictyostelium discoideum [Reaction:R-DDI-2090037] IDUA hydrolyses Heparan sulfate chain(6) - Dictyostelium discoideum [Reaction:R-DDI-2090085] HGSNAT oligomer acetylates Heparan chain(1) - Dictyostelium discoideum [Reaction:R-DDI-2090038] NAGLU hydrolyses heparan chain(2) - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-2024096] HS-GAG degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	HS-GAG degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-2024096
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1638091] Heparan sulfate/heparin (HS-GAG) metabolism
(hasEncapsulatedEvent)	[Pathway:R-DDI-2022928] HS-GAG biosynthesis
(inferredTo)	[Pathway:R-HSA-2024096] HS-GAG degradation

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