Reactome | Metabolism of nitric oxide: NOS3 activation and regulation

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Metabolism of nitric oxide: NOS3 activation and regulation Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11049714
displayName	Metabolism of nitric oxide: NOS3 activation and regulation
eventOf	[TopLevelPathway:R-DDI-1430728] Metabolism - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:18827] nitric oxide metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-DDI-203615] eNOS activation - Dictyostelium discoideum [Pathway:R-DDI-203754] NOSIP mediated eNOS trafficking - Dictyostelium discoideum
inferredFrom	[Pathway:R-HSA-202131] Metabolism of nitric oxide: NOS3 activation and regulation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Metabolism of nitric oxide: NOS3 activation and regulation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-202131
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-DDI-1430728] Metabolism
(hasEncapsulatedEvent)	[Pathway:R-DDI-1257604] PIP3 activates AKT signaling [Pathway:R-DDI-9009391] Extra-nuclear estrogen signaling [Pathway:R-DDI-8978934] Metabolism of cofactors
(inferredTo)	[Pathway:R-HSA-202131] Metabolism of nitric oxide: NOS3 activation and regulation

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