Reactome | AKT can phosphorylate RSK

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AKT can phosphorylate RSK Show undefined attributes

catalystActivity	[CatalystActivity:11006257] protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11006259
displayName	AKT can phosphorylate RSK
eventOf	[Pathway:R-DDI-198693] AKT phosphorylates targets in the nucleus - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferredFrom	[Reaction:R-HSA-199839] AKT can phosphorylate RSK - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-199877] RPS6KB2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	AKT can phosphorylate RSK
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-199844] phospho-p-S15,S356-RPS6KB2 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-199839
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-198693] AKT phosphorylates targets in the nucleus
(inferredTo)	[Reaction:R-HSA-199839] AKT can phosphorylate RSK