Reactome | PE is methylated to PC by PEMT

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PE is methylated to PC by PEMT Show undefined attributes

catalystActivity	[CatalystActivity:11016693] phosphatidylethanolamine N-methyltransferase activity of PEMT [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11016695
displayName	PE is methylated to PC by PEMT
eventOf	[Pathway:R-DDI-1483191] Synthesis of PC - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1483174] PE is methylated to PC by PEMT - Homo sapiens
input	3 × [SimpleEntity:R-ALL-71284] AdoMet [cytosol] [SimpleEntity:R-ALL-1500581] PE [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PE is methylated to PC by PEMT
output	3 × [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-DDI-1482667] 1-acyl LPE is acylated to PE by LPEAT - Dictyostelium discoideum [Reaction:R-DDI-1482646] 2-acyl LPE is acylated to PE by LPEAT - Dictyostelium discoideum [Reaction:R-DDI-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1483174
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1483191] Synthesis of PC
(inferredTo)	[Reaction:R-HSA-1483174] PE is methylated to PC by PEMT