Reactome | MLCL is hydrolyzed to DLCL by PLA2G4A (IM)

Schema > Reaction > Entries

MLCL is hydrolyzed to DLCL by PLA2G4A (IM) Show undefined attributes

catalystActivity	[CatalystActivity:11016494] A2-type glycerophospholipase activity of PLA2G4A:Ca2+ [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11016496
displayName	MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
eventOf	[Pathway:R-DDI-1482798] Acyl chain remodeling of CL - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM) - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-1498773] MLCL [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	MLCL is hydrolyzed to DLCL by PLA2G4A (IM)
output	[SimpleEntity:R-ALL-1498753] DLCL [mitochondrial inner membrane] [SimpleEntity:R-ALL-1524085] LCFA(-) [mitochondrial inner membrane]
precedingEvent	[Reaction:R-DDI-1482794] CL and 1-acyl LPC are converted to MLCL and PC by TAZ (IM) (Reversible) - Dictyostelium discoideum [Reaction:R-DDI-1482894] CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible) - Dictyostelium discoideum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1482759
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1482798] Acyl chain remodeling of CL
(inferredTo)	[Reaction:R-HSA-1482759] MLCL is hydrolyzed to DLCL by PLA2G4A (IM)