Reactome | FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster

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FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster Show undefined attributes

catalystActivity	[CatalystActivity:11016029] cysteine desulfurase activity of 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix]
category	omitted
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11016031
displayName	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster
eventOf	[Pathway:R-DDI-1362409] Mitochondrial iron-sulfur cluster biogenesis - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster - Homo sapiens
input	[Complex:R-DDI-1362401] 2 Iron:FXN:NFS1:ISD11:ISCU [mitochondrial matrix] 4 × [DefinedSet:R-DDI-2408372] FDX1,FDX2 (reduced) [mitochondrial matrix] 4 × [SimpleEntity:R-ALL-379721] L-Cys [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster
output	4 × [DefinedSet:R-DDI-2408370] FDX1,FDX2 (oxidized) [mitochondrial matrix] [Complex:R-DDI-1362398] FXN:NFS1:ISD11:ISCU:2Fe-2S Cluster [mitochondrial matrix] 4 × [SimpleEntity:R-ALL-379697] L-Ala [mitochondrial matrix]
precedingEvent	[Reaction:R-DDI-1362416] Frataxin binds iron - Dictyostelium discoideum [Reaction:R-DDI-2395512] FDXR transfers electrons to FDX1,2 (FDX1L) - Dictyostelium discoideum
regulatedBy	[Requirement:11016032] Requirement by 'FDX1,FDX2 (reduced) [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-1362408
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-1362409] Mitochondrial iron-sulfur cluster biogenesis
(inferredTo)	[BlackBoxEvent:R-HSA-1362408] FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster

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