Reactome | TFIIH [nucleoplasm]

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TFIIH [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:11001409] 3'-5' DNA helicase activity of TFIIH [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DDI-5689862] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-77053] RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-73716] RNA Polymerase I Transcription Initiation complex [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-73717] RNA Polymerase I promoter escape complex [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-6797611] Elongation Complex at DNA Repair Genes [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-75881] pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-75878] pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Dictyostelium discoideum [Complex:R-DDI-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] - Dictyostelium discoideum
consumedByEvent	[Reaction:R-DDI-109639] Formation of the closed pre-initiation complex - Dictyostelium discoideum [Reaction:R-DDI-5691000] TFIIH binds GG-NER site to form a verification complex - Dictyostelium discoideum [BlackBoxEvent:R-DDI-6781818] RNA Pol II initiates transcription from damaged DNA template - Dictyostelium discoideum [Reaction:R-DDI-112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein - Dictyostelium discoideum
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11000244
displayName	TFIIH [nucleoplasm]
hasComponent	[Complex:R-DDI-69221] CAK [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-67443] ERCC2 [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-67439] ERCC3 [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-65912] gtf2h1 [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-65914] gtf2h2 [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-65916] gtf2h3 [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-65918] gtf2h4 [nucleoplasm] [EntityWithAccessionedSequence:R-DDI-5688446] gtf2h5 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-109634] TFIIH [nucleoplasm] - Homo sapiens
maxDepth	3
name	TFIIH
producedByEvent	[Reaction:R-DDI-112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein - Dictyostelium discoideum [Reaction:R-DDI-75891] Abortive Initiation After Second Transition - Dictyostelium discoideum [Reaction:R-DDI-77090] Methylation of GMP-cap by RNA Methyltransferase - Dictyostelium discoideum [Reaction:R-DDI-73946] Abortive initiation after formation of the first phosphodiester bond - Dictyostelium discoideum [Reaction:R-DDI-75856] Abortive Initiation Before Second Transition - Dictyostelium discoideum
schemaClass	Complex
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-109634
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-DDI-73716] RNA Polymerase I Transcription Initiation complex [nucleoplasm] [Complex:R-DDI-73717] RNA Polymerase I promoter escape complex [nucleoplasm] [Complex:R-DDI-77061] CE:Pol II CTD:Spt5 complex [nucleoplasm] [Complex:R-DDI-77053] RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] [Complex:R-DDI-157174] Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] [Complex:R-DDI-157171] Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] [Complex:R-DDI-75902] pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] [Complex:R-DDI-75882] pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] [Complex:R-DDI-75881] pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] [Complex:R-DDI-75878] pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] [Complex:R-DDI-109878] pol II transcription complex [nucleoplasm] [Complex:R-DDI-83601] Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] [Complex:R-DDI-83591] RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] [Complex:R-DDI-109876] pol II open pre-initiation complex [nucleoplasm] [Complex:R-DDI-109635] pol II closed pre-initiation complex [nucleoplasm] [Complex:R-DDI-6797611] Elongation Complex at DNA Repair Genes [nucleoplasm] [Complex:R-DDI-6797607] CDK12-Phosphorylated Elongation Complex [nucleoplasm] [Complex:R-DDI-5689862] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] [Complex:R-DDI-6781821] Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] [Complex:R-DDI-6781822] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-DDI-6781861] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-DDI-9684119] Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-DDI-6782116] Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] [Complex:R-DDI-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-DDI-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-DDI-6782222] TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-DDI-6782220] TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-DDI-6782230] TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] [Complex:R-DDI-112433] Elongation complex [nucleoplasm] [Complex:R-DDI-75859] Pol II Promoter Escape Complex [nucleoplasm] [Complex:R-DDI-75890] pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm]
(input)	[Reaction:R-DDI-109639] Formation of the closed pre-initiation complex [Reaction:R-DDI-5691000] TFIIH binds GG-NER site to form a verification complex [BlackBoxEvent:R-DDI-6781818] RNA Pol II initiates transcription from damaged DNA template [Reaction:R-DDI-112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein
(output)	[Reaction:R-DDI-73946] Abortive initiation after formation of the first phosphodiester bond [Reaction:R-DDI-75891] Abortive Initiation After Second Transition [Reaction:R-DDI-77090] Methylation of GMP-cap by RNA Methyltransferase [Reaction:R-DDI-112383] Hypophosphorylation of RNA Pol II CTD by FCP1P protein [Reaction:R-DDI-75856] Abortive Initiation Before Second Transition
(inferredTo)	[Complex:R-HSA-109634] TFIIH [nucleoplasm]
(physicalEntity)	[CatalystActivity:11001409] 3'-5' DNA helicase activity of TFIIH [nucleoplasm]

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