Reactome | SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex

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SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex Show undefined attributes

catalystActivity	[CatalystActivity:10323591] ubiquitin-protein transferase activity of TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10323593
displayName	SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex
eventOf	[Pathway:R-CFA-5357905] Regulation of TNFR1 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Canis familiaris [BlackBoxEvent:R-CFA-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex - Homo sapiens
input	[Complex:R-CFA-9796343] TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] [Complex:R-CFA-8938763] Ub:UBE2L3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex LUBAC ubiquitinates RIPK1 at K627 in TNFR1 signaling complex
output	[Complex:R-CFA-9817363] TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] [EntityWithAccessionedSequence:R-CFA-8864201] UBE2L3 [cytosol]
precedingEvent	[Reaction:R-CFA-9796379] CYLD:SPATA2:LUBAC binds TNFR1 signaling complex - Canis familiaris
regulatedBy	[NegativeRegulation:10323594] Negative regulation by 'TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-9817362
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5357905] Regulation of TNFR1 signaling
(precedingEvent)	[BlackBoxEvent:R-CFA-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex [BlackBoxEvent:R-CFA-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex
(inferredTo)	[BlackBoxEvent:R-HSA-9817362] SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex

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