Reactome | Azathioprine ADME

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Azathioprine ADME Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331875
displayName	Azathioprine ADME
eventOf	[TopLevelPathway:R-CFA-9748784] Drug ADME - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-9751037] SLC28A2,3 cotransport 6MP and Na+ from extracellular region to cytosol - Canis familiaris [Reaction:R-CFA-9751024] SLC29A1,2 transport 6MP from extracellular region to cytosol - Canis familiaris [Reaction:R-CFA-9748996] GST dimers cleave AZA to 6MP - Canis familiaris [Reaction:R-CFA-9748983] TPMT transfers methyl group to 6MP, forming 6MeMP - Canis familiaris [Reaction:R-CFA-9748991] XDH oxidises 6MP to 6TU - Canis familiaris [Reaction:R-CFA-9748951] HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP - Canis familiaris [Reaction:R-CFA-9748979] TPMT transfers methyl group to 6TIMP, forming 6MeTIMP - Canis familiaris [Reaction:R-CFA-9748945] IMPDH tetramers dehydrogenate 6TIMP to 6TXMP - Canis familiaris [Reaction:R-CFA-9750546] ABCC4 transports TPMP substrates from cytosol to extracellular region - Canis familiaris [Reaction:R-CFA-9750617] ABCC5 transports TPMP substrates from cytosol to extracellular region - Canis familiaris [Reaction:R-CFA-9748957] GMPS dimer transforms 6TXMP to 6TGMP - Canis familiaris [Reaction:R-CFA-9748949] GUK1 phosphorylates 6TGMP to 6TGDP - Canis familiaris [Reaction:R-CFA-9748999] NME1:2 hexamer phosphorylates 6TGDP to 6TGTP - Canis familiaris [Reaction:R-CFA-9748963] GUK1 phosphorylates 6TdGMP to 6TdGDP - Canis familiaris [Reaction:R-CFA-9748969] NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP - Canis familiaris [Reaction:R-CFA-9750555] NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP - Canis familiaris [Reaction:R-CFA-9751201] p-VAV1,2,3 exchange 6TGTP for GDP on RAC1 - Canis familiaris
inferredFrom	[Pathway:R-HSA-9748787] Azathioprine ADME - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Azathioprine ADME
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-9748787
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-CFA-9748784] Drug ADME
(inferredTo)	[Pathway:R-HSA-9748787] Azathioprine ADME

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